Brief Communications Prefrontal Cortex Fails to Learn from Reward Prediction Errors in Alcohol Dependence
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چکیده
Soyoung Q Park,1,2* Thorsten Kahnt,1,3* Anne Beck,1 Michael X Cohen,4,5 Raymond J. Dolan,6 Jana Wrase,1* and Andreas Heinz1* 1Department of Psychiatry and Psychotherapy, Charité–Universitätsmedizin Berlin, 10117 Berlin, Germany, 2Neurocognition of Decision Making Group, Max Planck Institute for Human Development, 14195 Berlin, Germany, 3Bernstein Center for Computational Neuroscience, 10115 Berlin, Germany, 4Department of Psychology, University of Amsterdam, 1018 WB Amsterdam, The Netherlands, 5Department of Physiology, University of Arizona, Tucson, Arizona 85724, and 6Wellcome Trust Centre for Imaging Neuroscience, University College London, London WC1N 3BG, United Kingdom
منابع مشابه
Prefrontal cortex fails to learn from reward prediction errors in alcohol dependence.
Patients suffering from addiction persist in consuming substances of abuse, despite negative consequences or absence of positive consequences. One potential explanation is that these patients are impaired at flexibly adapting their behavior to changes in reward contingencies. A key aspect of adaptive decision-making involves updating the value of behavioral options. This is thought to be mediat...
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تاریخ انتشار 2010